منابع مشابه
Pregnancy Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat Pregnancy
Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler. Doxycycline inhibits matrix metalloproteinase activity. We tested the hypothesis that matrix metalloproteinase inhibition reduces trophoblast invasion with subsequent ...
متن کاملSpiral artery remodeling in preeclampsia revisited.
T he first observations that placental bed defects were potentially linked to clinical outcomes such as pre-eclampsia (PE) were made nearly 50 years ago. 1 This study followed prior findings that the placental clearance of radio-labeled saline was significantly decreased in women with hypertensive gestations. 2 Histological examination of pla-centas and placental bed biopsies obtained from comp...
متن کاملUterine natural killer cells initiate spiral artery remodeling in human pregnancy.
Uterine spiral artery remodeling is required for successful human pregnancy; impaired remodeling is associated with pregnancy complications, including late miscarriage, preeclampsia, and fetal growth restriction. The molecular triggers of remodeling are not known, but it is now clear that there are "trophoblast-independent" and "trophoblast-dependent" stages. Uterine natural killer (uNK) cells ...
متن کاملInhibition of trophoblast-induced spiral artery remodeling reduces placental perfusion in rat pregnancy.
Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler. Doxycycline inhibits matrix metalloproteinase activity. We tested the hypothesis that matrix metalloproteinase inhibition reduces trophoblast invasion with subsequent ...
متن کاملUterine Spiral Artery Remodeling Involves Endothelial Apoptosis Induced by Extravillous
Sandra V. Ashton, Guy St. J. Whitley, Philip R. Dash, Mark Wareing, Ian P. Crocker, Philip N. Trophoblasts Through Fas/FasL Interactions Uterine Spiral Artery Remodeling Involves Endothelial Apoptosis Induced by Extravillous Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2004 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the...
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ژورنال
عنوان ژورنال: Open Access Journal of Translational Medicine & Research
سال: 2017
ISSN: 2576-4578
DOI: 10.15406/oajtmr.2017.01.00015